Topic

DHT

16 articles, newest first.

ResearchDHTGene Therapy
Prostaglandin D2: The Hidden Brake on Hair Growth That Scientists Have Known About Since 2012
A decade ago, a landmark study identified PGD2 as a potent inhibitor of hair follicle growth, elevated in bald scalp. Why is no approved treatment targeting it yet?
May 13, 2026·about 2 months ago·Liam Foster
Clinical TrialsDHT2030 Cure
What Pyrilutamide Getting to Phase 3 Actually Means for Men With Hair Loss
Kintor Pharmaceutical's CB-03-01 successor has reached Phase 3 trials in the US and China. It is the most promising topical androgen receptor blocker in a generation, and the reason that matters goes beyond the obvious.
May 12, 2026·about 2 months ago·Dr. Maya Chen
Clinical TrialsDHTAntiandrogens
Clascoterone Phase 3 Data Is In, And It's More Complicated Than the Headlines Suggest
The first topical antiandrogen to complete Phase 3 for androgenetic alopecia showed meaningful hair density improvements, but the effect size tells a more nuanced story than its proponents acknowledge.
May 11, 2026·about 2 months ago·Dr. Maya Chen
MinoxidilClinical TrialsDHT
Oral Minoxidil at 1.25mg Is Working Differently to What Anyone Expected
Low-dose oral minoxidil has become one of the most prescribed off-label treatments in dermatology. The 2025 real-world data from 1,200 patients across three countries confirms the efficacy, and complicates the safety picture in ways worth understanding.
May 6, 2026·about 2 months ago·Liam Foster
ResearchInflammationDHT
Your Scalp Has a Microbiome. It Might Be Contributing to Your Hair Loss.
Research into the scalp microbiome is revealing links between bacterial and fungal communities and hair loss that go beyond simple dandruff. The therapeutic implications are only beginning to be explored.
May 2, 2026·2 months ago·Liam Foster
DHTClinical TrialsFinasteride
Dutasteride Mesotherapy vs Oral: A Head-to-Head Comparison the Field Has Been Waiting For
Intradermal injection of dutasteride directly into the scalp has been practiced by dermatologists for years. A 2025 randomised trial is the first to rigorously compare it to the oral version, and the results have implications for how we think about systemic drug exposure.
May 1, 2026·2 months ago·Dr. Maya Chen
FinasterideDHTClinical Trials
Finasteride at 10 Years: The Most Important Long-Term Safety Study Yet Published
A prospective 10-year study of finasteride 1mg for androgenetic alopecia, the longest rigorous follow-up ever conducted, has data on efficacy maintenance, sexual side effects, and cardiovascular outcomes that every user should know.
Apr 25, 2026·2 months ago·Liam Foster
FinasterideDHTResearch
Topical Finasteride Is Safer Than Oral, But the Pharmacokinetic Data Tells a More Complicated Story
The pitch for topical finasteride is straightforward: get the hair regrowth without the systemic side effects. The pharmacokinetic data shows the picture is more nuanced than the marketing suggests.
Apr 15, 2026·3 months ago·Liam Foster
Female Pattern Hair LossDHTResearch
Spironolactone for Female Pattern Hair Loss: The Most Underprescribed Effective Treatment
Spironolactone has been used off-label for female pattern hair loss for forty years. The 2024 systematic review finally collated the evidence base, and the picture is more positive than its niche status would suggest.
Apr 13, 2026·3 months ago·Dr. Maya Chen
ResearchDHTNutrition
Saw Palmetto for Hair Loss: A Mechanism Without Clinical Evidence
Saw palmetto extract is in dozens of hair loss supplements. The 5-alpha reductase inhibition is real in vitro. The clinical evidence remains stubbornly thin.
Mar 20, 2026·4 months ago·Liam Foster
Female Pattern Hair LossDHTResearch
PCOS and Hair Loss: Treatment Considerations for the Underlying Endocrinology
Polycystic ovary syndrome affects 10–15% of women of reproductive age. Hair loss is a common feature, and treating it without addressing the underlying endocrinology often fails.
Mar 3, 2026·4 months ago·Dr. Maya Chen
ResearchNutritionDHT
Pumpkin Seed Oil for Hair Loss: A Surprising Trial With Replication Pending
A 2014 Korean trial reported substantial hair count improvements from oral pumpkin seed oil. The methodology was unusual and replication is overdue, but the mechanism is plausible.
Feb 19, 2026·5 months ago·Liam Foster
ResearchDHTClinical Trials
Setipiprant: The PGD2 Antagonist That Almost Was
Setipiprant blocks the prostaglandin D2 receptor implicated in androgenetic alopecia. The drug had a promising mechanism and a disappointing development path. Here's what happened.
Dec 28, 2025·6 months ago·Liam Foster
ResearchLifestyleDHT
Smoking and Androgenetic Alopecia: An Independent Risk Factor With a Plausible Mechanism
Multiple epidemiological studies have linked smoking to accelerated androgenetic alopecia. The relationship survives statistical adjustment, and the proposed mechanism makes biological sense.
Dec 16, 2025·7 months ago·Dr. Maya Chen
DHTFinasterideTreatment
Dutasteride vs Finasteride for Androgenetic Alopecia: When to Choose Each
Dutasteride blocks both 5-alpha reductase isoforms; finasteride blocks only type 2. The clinical comparison shows dutasteride wins on efficacy and loses on side effect profile.
Oct 17, 2025·9 months ago·Dr. Maya Chen
DHTTreatmentResearch
Hair Loss in Trans Men on Testosterone: Pattern and Timing
Testosterone therapy for transmasculine patients reproduces the androgen environment that drives male pattern hair loss. Timing, pattern, and treatment considerations differ from cisgender presentations.
Aug 11, 2025·11 months ago·Liam Foster

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DHT

Prostaglandin D2: The Hidden Brake on Hair Growth That Scientists Have Known About Since 2012

What Pyrilutamide Getting to Phase 3 Actually Means for Men With Hair Loss

Clascoterone Phase 3 Data Is In, And It's More Complicated Than the Headlines Suggest

Oral Minoxidil at 1.25mg Is Working Differently to What Anyone Expected

Your Scalp Has a Microbiome. It Might Be Contributing to Your Hair Loss.

Dutasteride Mesotherapy vs Oral: A Head-to-Head Comparison the Field Has Been Waiting For

Finasteride at 10 Years: The Most Important Long-Term Safety Study Yet Published

Topical Finasteride Is Safer Than Oral, But the Pharmacokinetic Data Tells a More Complicated Story

Spironolactone for Female Pattern Hair Loss: The Most Underprescribed Effective Treatment

Saw Palmetto for Hair Loss: A Mechanism Without Clinical Evidence

PCOS and Hair Loss: Treatment Considerations for the Underlying Endocrinology

Pumpkin Seed Oil for Hair Loss: A Surprising Trial With Replication Pending

Setipiprant: The PGD2 Antagonist That Almost Was

Smoking and Androgenetic Alopecia: An Independent Risk Factor With a Plausible Mechanism

Dutasteride vs Finasteride for Androgenetic Alopecia: When to Choose Each

Hair Loss in Trans Men on Testosterone: Pattern and Timing